St Joan Antide School was inaugurated in 1964 by Mons. Archibishop Gonzi. At the beginning the school consisted of two classes and only catered for students who come from the same locality. Along the years more parents expressed their wish for their children to be enrolled and by time students started joining from all around the island. At the time the school also offered after school training in life skills such as sewing. By the time the school population progressed up to Year 6 it was not possible for all teachers to be Sisters of Charity so lay teachers started to be employed. The first Head of School was Sr Antonia Falzon. Due to the change of demands during the nineteen eighties the school administration feelt the need to enlarge the premises. Another floor was built to accommodate more classrooms and in 1996 all the primary section of Immaculate Conception School was transferred to Gudja. As time went by the primary school changed from a Co-Ed to a girls school. Following this transition the girls in the primary school had a reserved place in the secondary school in Tarxien.

The secondary school is adjacent to the main convent of the Sisters of Charity. The premises was under the direct responsibility of the orderof the Sisters of Charity as of 1902. In 1944 secondary schooling for girls was started. The first Head of School was Sr Filippina Frendo Cumbo and she was helped by other sisters. In 1950 the students attending Immaculate Conception were some of the first students in Malta sitting for GCE Oxford as the sisters believed in the need for good education and certification to be well equipped for service in society. During the nineteen fifties the Sisters of Charity contributed to the pastoral wellbeing of the community in Tarxien. The educational needs of the time led the to the continued improvement of the premises and more floors were added to the basic structure. This led to the introduction of science laboratories followed by computer, food, textiles, and health and social care laboratories. The biggest investment to date was the fully fletched gym and a state of the art auditorium that were built in the garden area which was part of the convent.